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Vaska’s complex- Reagent of the month

Iridium is ubiquitous in organic synthesis. In the last decade alone we have seen its impact as a phtoredox catalyst for a wide range of light-driven reactions that are difficult to achieve using traditional synthetic methods.1 In addition, iridium has rich utility in C-H activation chemistry- a recent review by Cramer highlighting chiral complexes as

Interview with Dr David Leahy, Takeda Pharmaceuticals, USA

Dr John Studley, Scientific Director at Scientific Update recently spoke to Dr David Leahy, Takeda, USA ahead of his presentaion at the 2019 Catalysis in the Pharmaceutical and Fine Chemical Industry Conference in Lucerne, Switzerland. David will talk about “A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis”- following on from his paper published recently in Organometallics

What is the simplest marketed therapeutic?

Lithium (Li, Element 3) Lithium, first member of the group 1 alkali metals, was discovered in 1817 by Johan August Arfwedson. It’s been around since the dawn of (astronomical) time- both stable isotopes, Li6 and Li7, being among a small handful of elements created in the Big Bang.1Terrestrially its highly abundant in seawater (up to

Oiling the cogs- Practical tips, useful facts and resources: Organometallic highlight:

The generation of lithium-alkoxide based aryl and heteroaryl Grignard reagents by Mg-Br/Cl exchange in toluene- increased reactivity and wide applicability. Organomagnesium-based organometallics are used extensively in organic chemistry.[1] Historically the reagents were prepared by direct insertion of magnesium metal into organic halides. With demand for more industrially applicable methods, halogen-magnesium exchange using alkyl magnesium halides

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