If you are working in industry and are responsible for safety, how do you safely scale up a given chemical reaction? How do you tackle issues like heat transfer, gas release, exposure control, waste stream issues and more? The core of any process safety study is a correct description of both heat and gas release

Nirmatrelvir, the active ingredient of the Pfizer drug Paxlovid (Figure 1), is an inhibitor of the SARS-CoV-2 main protease enzyme.1 A key transformation- the final synthetic step in the synthesis of Nirmatrelvir- is dehydration of a primary amide (Figure 2).The amide starting material is prepared by reaction of the corresponding ester with ammonia.2 Various methods

Many organic impurities, such as nitrosamines, are known to be harmful to human health. Therefore, regulatory bodies and government set strict limits to protect us all. Even in small quantities, pharmaceutical impurities can have serious negative health impacts and influence the behaviour and efficacy of a drug. Organic impurities fall into a number of categories.

We spoke to chemists at different stages of their careers about their experiences of attending our ‘Chemical Development and Scale Up in the Fine Chemical and Pharmaceutical Industries’ training course. Ben Littler  Ben told us that he had taken the ‘Chem Dev’ course twice as an early career process chemist!  Both courses were held as

What an experience to treasure! Claire and Hannah from Scientific Update Ltd were invited to travel on the beautiful British Pullman last week, for a specially hosted event ‘Golden Age of Travel with The Netherlands’. Passengers were encouraged to dress up in 1920’s costume and it certainly was a rather glamorous and special occasion. Everyone enjoyed fine

Our ‘Young Chemist Award’ – This competition helps young PhD chemists reach out to a wider industrial audience and gain recognition for their work. It can also help boost confidence as each finalist gets to present their work in a short presentation. Being selected as a finalist and getting the opportunity to present is in

We are very pleased to introduce Dr Jen Crawford from GSK.  Jen will be talking about ‘Implementing Statistical Modelling Tools into Early Phase Process Development Workflows’ at our ‘Organic Process Research and Development Conference’ in New Orleans on 22-24 June. This presentation will describe high throughput experiments (HTE) which provide an opportunity to traverse large

The count down has begun and we only have one month to go now until we come to New Orleans for our ‘47th Organic Process R&D Conference’ on 22-24 June. We are so excited about holding this face to face event in such a vibrant brilliant location!  The 3 day meeting will include 16 presentations

To celebrate International Women’s Day 2022  – Helen Spencer (Consultant BDM and Marketer) asked Scientific Update Ltd joint owners and Directors Dr Claire Francis and Hannah May – a few questions about their career journey. Q: Do you think it is important to celebrate International Women’s Day? A: CF: Yes, for me it is an

The Scientific Update Team had a brilliant evening having dinner and listening to the Jazz on The Pantiles in Royal Tunbridge Wells.  To be together celebrating that we are still very much here and have survived the most challenging 18 months in our history, was really rather special. We can’t wait to see you all