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How do you safely scale up a given chemical reaction?

If you are working in industry and are responsible for safety, how do you safely scale up a given chemical reaction? How do you tackle issues like heat transfer, gas release, exposure control, waste stream issues and more? The core of any process safety study is a correct description of both heat and gas release

Call For Papers 2021

Do you have a topic that you would like to share with our international audience of organic chemists? We are currently inviting speakers to present technical papers at our events this year.   Flow Chemistry & Continuous Processing Conference – ONLINE – 10-11 May Catalysis in the Fine Chemicals Industries Conference – ONLINE – 2-3

In full flow-continuously battling bacteria with boron

Increasing multidrug resistance to antimicrobial agents, particularly in Gram-negative bacteria, is a significant global healthcare challenge. Carbapenem-resistant enterobacteriaceae (CRE) has been declared as one of the most urgent drug-resistant threats in the United States. Much like the cephalosporin B-lactams in the 1980’s, heavy clinical reliance on carbapenem b-lactam antibiotics over the past few decades has

Utilization of fluoroform for difluoromethylation in continuous flow: a concise synthesis of α-difluoromethyl-amino acids

Published in Green Chemistry in 2018 C. Oliver Kappe is our tutor on our Flow Chemistry course and this abstract was published in Green Chemistry showing a collaboration with Lonza in making an API in flow. Abstract: Fluoroform (CHF3) can be considered as an ideal reagent for difluoromethylation reactions. However, due to the low reactivity

OPRD US 2018 Conference

We had a fantastic turn out for our #OPRDUS18 Conference in Clearwater, Florida last month. It was great to see our speakers, exhibitors and attendees and the feedback we received was excellent. Thank you for coming along! Our Technical Director Dr Will Watson opened the conference and we invited Dr Paul Murray and Dr André de

Reaction Calorimetry in Microreactor Environments

Flow chemistry is big news at the moment, but one of the issues from a scale up perspective has been carrying out some of the process hazard analysis, and in particular reaction calorimetry.  If reactants are unstable either thermally or chemically is it possible to get meaningful results from a conventional reaction calorimeter?  A recent

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