There are now 3 cocrystal API’s (Entresto, Suglat, and Depakote) on the market meaning that this area is no longer just an academic curiosity. Entresto is a cocrystal formed from the sodium salts of sacubitril and valsartan, but I do not know whether that is affected by the current furore over N-nitrosoamine impurities found in
Tag: API
Medicinal chemists love introducing aromatic rings into their pharmacophores. These flat rings make important lipophilic and pi-stacking interactions with proteins and are good synthetic handles for attaching functionality to reach and bind to all the nooks and crannies of an active site. With the advent of cross-coupling chemistry and the simplicity and efficiency of transition