As someone who did his PhD on photochemistry, I have always been surprised at how little photochemistry is used in making new molecules, given the unusual transformations that photochemistry can enable. However, there has been a resurgence in the use of photochemistry in the last decade in academic laboratories. But the equipment had hardly changed in the 50 years since I started my PhD. Now, the group of MacMillan at Princeton and Merck researchers at Rahway, New Jersey have devised a new, more efficient integrated photoreactor (ACS Central Science, 2017, 3, 647-653) that has been engineered to simplify lab use, optimise photon capture and speed reactions. The equipment comprises a modular LED source, a holder for 2-40ml vials and a reflector for maximising light usage and additional safety features. The reactor was tested on eight photoreactions including trifluoromethylations, decarboxy-fluorination and photocatalytic C-N coupling.
New Small-Scale Photoreactor
Recent articles from the lab
Living in a “Material World”
Written by Jonathan Moseley, April 17th 2024 No relation to the Madonna song, but rather the title of a book by Ed Conway, an economist and journalist, regarding the Material World in which we live. And if like me, you have a general interest in chemistry, as well as some interest in economics and history…
Put and Take Shakes It Up
In this post I’m highlighting a couple of papers that are essentially two sides of the same coin. As a process chemist, I’ll be the first to admit that the chemistry I’m about to describe is not going to end up in your manufacturing route any time soon, but as a former card-carrying medicinal chemist…
Some Elements are More Equal Than Others
In George Orwell’s classic 1945 novella ‘Animal Farm’ the revolutionary livestock develop the slogan “Four legs good, two legs bad” to summarize their views on the farmer and other humans. As the novella progresses, we see that things cannot be simplified so readily, and so I was encouraged by the recent excellent article by Brianna…