Francis Arnold and her group have published a series of papers using modified Cytochrome P450 enzymes to cyclopropanate olefins with diazo esters1. More recently they have used a related system to create chiral carbon-silicon bonds2.
- P.S. Coelho, E.M. Brustad, A. Kannan, and F.H. Arnold et al, Science, 2013, 339, 307-310; Z.J. Wang, H. Ranata, N.E. Peck, C.C. Farwell, P.S Coelho, and F.H Arnold, Angew. Chem. Int. Ed., 2014, 53, 6810.
- S.J.B. Kan, R.D. Lewis, K. Chen, and F.H Arnold, Science, 2016, 354, 1048-1051.