Allotrope Scientific Ltd is a UK based practice providing holistic CMC expertise in chemical process design, development and scale-up of small molecule drug substances compliant to regulatory requirements.

Durham, UK

+44.794.794.2709
[email protected]

Home

Allotrope Scientific Ltd

At core, Allotrope Scientific Ltd provides scientific and technical expertise in developing a robust and sustainable process to take your molecule from lab to market.

From phase appropriate route scouting, solid form selection to route development, process characterisation, particle engineering and validation; we guide all the way from preclinical to commercial supply, including authoring of your drug substance regulatory filings. If necessary, we are also resourceful in helping you find the right partner for development and manufacture, and sourcing of reliable suppliers of key starting materials.

We are passionate about organic chemistry and enjoy the art of organic synthesis. Recently, we have expanded into providing custom synthesis of 14C radiolabelled intermediates and APIs. We enjoy problem solving and developing an understanding of what happens in a reaction. This helps us in supporting you with syntheses and supply of challenging impurities.

Arcinova is a UK-based Contract Development and Manufacturing Organisation (CDMO) serving the global pharmaceutical and biotechnology communities.

Taylor Drive
Alnwick
Northumberland
United Kingdom
NE66 2DH

+44 (0) 1665 608 567 – Office
arcinova.uk

Arcinova

Arcinova is a UK-based Contract Development and Manufacturing Organisation (CDMO) serving the global pharmaceutical and biotechnology communities.

From our single 15,000m2 facility, which has benefited from more than 36 years of investment as a key R&D centre for Sanofi and Covance, we can support our clients’ needs with a wide range of services such as: drug substance development and manufacturing (including GMP, [14C]-labelled products and high potents), material sciences, formulation and drug product manufacturing.

We can manufacture both drug substance and drug products from grams to multi-kilo scale.

We also offer supporting analytical services including, investigations and development of QC specifications, microbiological and stability testing as well as a regulatory CMC dossier writing service.

Finally, our experienced bioanalytical team can develop, validate and implement bioanalytical assays for small and large molecule drugs, generics and biomarkers to support both clinical and non-clinical studies.

Binger Strasse 173
55216 Ingelheim am Rhein

+49 – 6132 – 77 0
[email protected]
https://www.boehringer-ingelheim.com/

Boegringer Ingelheim

Boehringer Ingelheim is working on breakthrough therapies that transform lives, today and for generations to come. As a leading research-driven biopharmaceutical company, the company creates value through innovation in areas of high unmet medical need. Founded in 1885 and family-owned ever since, Boehringer Ingelheim takes a long-term perspective. More than 52,000 employees serve over 130 markets in the three business areas, Human Pharma, Animal Health, and Biopharmaceutical Contract Manufacturing. Learn more at www.boehringer-ingelheim.com

A world leader in providing unique state-of-the-art protein engineering and enzyme optimization services that can be applied in the development of biocatalysts for chemical manufacturing.

200 Penobscot Drive

Redwood City

CA 94063

 

T: 650 421 8388

W: www.codexis.com

E: [email protected]

Codexis

Our proprietary CodeEvolver® protein engineering technology platform enables the rapid development of highly optimized proteins, custom-designed for our clients’ specific therapeutic or process-relevant applications.

Digital Specialty Chemicals (DSC), based in Toronto, Canada, develops and manufactures high-quality organophosphorus and organometallic chemicals for the pharmaceutical, specialty chemical and electronic-materials markets.

470 Coronation Drive

Toronto, ON M1E 4Y4, Canada

 

T: Dilleny Kawiratne (416) 231-2991 ext. 116

W: www.digitalchem.com

E: [email protected]

Digital Specialty Chemicals

DSC’s product line includes phosphine ligands (including Buchwalds) for homogeneous catalysis, phosphorylating reagents and challenging organometallics, available from kilogram to metric ton quantities. DSC offers custom manufacturing services, with focus on air, moisture and heat sensitives.  WE MAKE CHEMISTRY MATTER.

FCG develops microwave driven, continuous flow processes and engineers scale-up solutions.

FCG Chemical
3710 Buckeye Street
Suite 120
Palm Beach Gardens, FL 33410

T: +1-561-282-6520
W: http://fcgchemicals.com
E: [email protected]

FCG Chemical

FCG Chemical works with clients to develop flow processes using our microwave reactor test platform.  By using our flexible suite of reactors, we offer a rapid pathway to identifying the economic advantages of microwave driven, flow chemistry.  Our reactor technology is flexible, modular and can be customized to match production needs.

Our scientists are engaged in research and development in the fields of chemistry and energy technology (processes, reactors, plants) and analysis systems and sensors (methods, components, systems).

Carl-Zeiss-Str. 18-20

55129 Mainz

Germany

 

T: +49 6131 990-0

W: https://imm.fraunhofer.de/

E: [email protected]

Fraunhofer ICT-IMM

The core competencies in continuous chemical engineering include development and simulation based design of micro reactors, realization of plants for lab, pilot and production scale and process development based on microreactors and flow chemistry.

Huber

Huber UK and Ireland Ltd is a wholly owned subsidiary of Peter Huber Kaltemaschinenbau AG a technology leader for high precision thermoregulation solutions  in research and industry….

Huber UK & Ireland Ltd

Unit 7, Heritage Business Centre
Derby rd
Belper DE56 1SW

Contact Phone: +44 1773 82 3369
Website: www.huber-uk.co.uk
Email: [email protected]

Huber

With service and store facilities in Derbyshire and Dublin, Huber UK and Ireland are ideally situated to support your application form small to large scale chemistry.  Our products ensure precise temperature control in laboratories, pilot plants and production processes throughout the whole world – from -125 °C to +425 °C.  Besides dynamic temperature control systems we develop and produce chillers as well as classic heating and cooling circulators. For many applications we supply custom-tailored solutions, which we develop in cooperation with our customers.

Innosyn has an unbiased approach to “invent, improve and/or implement” the best process for your challenging chemistry.

InnoSyn BV
Urmonderbaan 22
6167 RD Geleen
The Netherlands

+31 46 4760525
innosyn.com

Innosyn

Innosyn has an unbiased approach to “invent, improve and/or implement” the best process for your challenging chemistry.

JULABO is the market leader in laboratory, chemical reactor & pilot plant temperature control systems.

884 Marcon Boulevard

Allentown, PA 18109

 

T: +1 610-231-0250       or       F: +1 610-231-0260

W: www.julabo.us // www.autoreactors.com

E: [email protected]

JULABO USA, Inc.

The NEW Presto units cover every temperature application from- 92°C to +250°C from bench top to pilot plant scale.

Keit provides rugged technology for in-line process monitoring of liquids. The IRmadillo™ FTIR spectrometer uses the power of mid-infrared with solid-state design to enable real-time reaction analysis for manufacturing industries.

Keit Ltd.

Unit 4, Zephyr Building
8th Street, Harwell Campus
Didcot
Oxfordshire
OX11 0RL
United Kingdom

Tel: +44 (0)1235 431260

Email: [email protected]
Website: www.keit.co.uk

 

Keit Spectrometers

Keit is a technology-driven company launched from the European space programme with applications in the global marketplace. Keit offers real-time reaction analysis of liquids in manufacturing processes of chemicals, oil & gas, biofuels, and food & beverages with a solid-state instrument.  The IRmadillo FTIR spectrometer provides in-line process monitoring in challenging environments where standard instruments fail.

Jim Rutherford from Keit presented a paper at ‘4th Hazardous Chemistry Conference for Streamlined Large Scale Synthesis‘ in Antwerp, November 28th & 29th 2017. You can view his presentation using the link below:

Keit Presentation

Key Organics is a UK based CRO, providing chemistry support from mg to kg for over 35 years.

Key Organics Ltd
Highfield Road Industrial Estate
Camelford
Cornwall
PL32 9RA
UK

https://www.keyorganics.net/

[email protected]

+44 (0) 1840 21213

Key Organics Ltd

Key Organics has over 30 years’ proven expertise and competence, supplying to a global client base our high quality ‘BIONET’-branded catalogue products (>200,000) for early-stage drug discovery research.

Product lines include; Fragments, Biochemicals, Screening Compounds, Research Intermediates, AgrimediatesTM and Core Scaffolds.

We also have extensive experience in the delivery of bespoke Chemistry Services, e.g. Custom & Contract Synthesis and Collaborative R&D. We have an enviable reputation in FTE services provision from our highly-qualified and skilled team of chemists.

Operating out of our own premises in Cornwall, we cater primarily for the pharmaceutical, biotechnology and agro/petrochemical industries.

Lhasa Limited

Lhasa Limited draws upon over 30 years of experience to create state-of-the-art in silico prediction and database systems for use in a variety of workflows including regulatory submissions.

Granary Wharf House

2 Canal Wharf

Leeds, LS11 5PS

 

T: +44 113 394 6020

W:  https://www.lhasalimited.org/

E:   [email protected]

Lhasa Limited

Lhasa’s software includes Mirabilis, an expert knowledge-based tool for calculating the purge factors of potentially mutagenic impurities, as well as Derek and Sarah Nexus, which can help with ICH M7 submission.

Founded in 2004, Magritek is the global leader in manufacturing cryogen-free benchtop Nuclear Magnetic Resonance (NMR) spectrometers for the analytical instrument market. Magritek’s revolutionary 80 MHz, 60 MHz and 43 MHz Spinsolve family of benchtop NMR models offer the highest sensitivity and resolution available in the market.

Magritek GmbH
Philipsstrasse 8
52068  Aachen, Germany
Phone: +49 241-92787-2725
Mail: [email protected]

Web  http://www.magritek.com

Magritek

Founded in 2004, Magritek is the global leader in manufacturing cryogen-free benchtop Nuclear Magnetic Resonance (NMR) spectrometers for the analytical instrument market. Magritek’s revolutionary 80 MHz, 60 MHz and 43 MHz Spinsolve family of benchtop NMR models offer the highest sensitivity and resolution available in the market.  These portable systems are robust and easy to use, allowing modern NMR methods to be performed on the chemistry lab bench or inside the fume hood next to a reactor. Magritek has offices in Germany, USA, and New Zealand, as well as a worldwide network of partners, to help support its customers. Learn more at www.magritek.com.

 

Patheon

Patheon is a leading global provider of pharmaceutical development and manufacturing services.

4815 Emperor Blvd Ste 300

Durham, NC 27703

 

T: 919 226 3200

W: www.patheon.com

E: [email protected]

Patheon

With approximately 8,700 employees worldwide, Patheon provides a comprehensive, integrated and highly customizable set of solutions to help clients of all sizes satisfy complex development and manufacturing needs at any stage of the pharmaceutical development cycle. A Healthier World. Delivered.

Powder Systems Ltd

Manufacturer of Innovative Technologies and Process Equipment that accelerate and improve manufacturing in the field of API or Complex Injectable Forms.

8 Estuary Banks
Liverpool
Merseyside, L24 8RG
United Kingdom

Email:        [email protected]
Website:    https://www.powdersystems.com/

Powder Systems Ltd

Powder Systems Ltd (PSL) is an award-winning global manufacturer of innovative technologies and process services for the pharmaceutical, bio-pharmaceutical and chemical industries.

With a successful track record, built up over the last 30 years, PSL is widely recognised for its high level of quality and expertise in pharmaceutical and chemical processing. We provide a full range of filtration and drying process systems from small R&D up to larger commercial production scale, which can also be combined with our containment systems for advanced operator protection.

Our pioneering solutions enable pharmaceutical manufacturers to improve their processes and adopt the latest advances to produce their medicines in a safer, better and more cost-effective way. Our technology is used within the industry every day, from early development works with our GFD® range (filtration & drying of powders), to new-generation drugs with the MSR™ platform for complex microsphere based injectables.

Radleys – developing and providing innovative productivity tools to help chemists discover amazing things. At Radleys, we know that chemists are always searching for better ways to do what they do. Our innovative products enable more productive chemistry that is safe, sustainable and exciting.

Radleys
Shire Hill
Saffron Walden
Essex, CB11 3AZ
United Kingdom

t: +44 1799 513320
e: [email protected]
w: www.radleys.com

Radleys

Changing the way you do chemistry.

Chemistry isn’t just something we do. It’s everything we are.

We’ve been manufacturing scientific glassware and laboratory instruments for over 50 years. Committed to innovation, all of our products are designed to give users the flexibility and freedom to conduct chemical research in the way they want.

Scale is no barrier – from research to development, benchtop to production, we create the tools needed for safer, cleaner, greener, more productive chemistry. With in-house research and development facilities, we focus on equipment for chemical synthesis and process development.

Accelerate to the next phase with our advanced catalyst and ligand technologies.

820 Bear Tavern Road
West Trenton
New Jersey
08629
USA

W:  http://en.sinocompound.com/
E:  [email protected]

Sinocompound

Sinocompound is a global provider of advanced homogeneous catalysts and ligands and specialist services for a range of pharmaceutical and fine chemical applications. Our proven process is built around our next generation technologies, flexibility, and speed-of-response ensuring delivery at the scale required for your project. Our success is due to our dedication to listening to customers and developing bespoke solutions that help the industry overcome its challenges and customers accelerate their route to market.

SK pharmteco specializes in the commercial and clinical production of APIs, Advanced Intermediates, Registered Starting Materials, Key Building Blocks and Viral Vectors. Our offerings include process R&D, analytical method development and stability, scale-up and optimization, validation and commercial production.

Swords Campus,
Watery Lane,
Swords,
Co Dublin,
Ireland

+353 1 8139000
[email protected]

Home

SK Pharmteco

Profile

SK pharmteco specializes in the commercial and clinical production of APIs, Advanced Intermediates, Registered Starting Materials, Key Building Blocks and Viral Vectors. Our offerings include process R&D, analytical method development and stability, scale-up and optimization, validation and commercial production. Additionally, we offer extensive AAV and Lentiviral vector development and cGMP production capabilities.

Our global operations include 7 cGMP manufacturing and development facilities across the US, Korea, Ireland and France. We also operate a dedicated analytical services facility.

SK pharmteco is a leader in operational excellence and continuous improvement. Our highly skilled team delivers innovative solutions utilizing advanced technologies:
– Continuous Flow Processing
– Chromatography: SMB & Batch
– High Potency (Up to 4 m³ scale & down to 10 ng/m³
containment)
– Energetic Chemistry
– Controlled Substances (Sch II-V Manufacturing)
– Particle Engineering
– cGMP Manufacturing in Adherent & Suspension Systems for
Viral Vectors
– Analytical & Process Development for Viral Vectors

We have a strong record of environmental, health, and safety performance. All our plants have been successfully audited by global regulatory agencies including the FDA (US), EMA (Europe), PMDA (Japan), & MFDS (Korea).

Strong technology toolbox & ~1,000 m³ of global small-molecule capacity + 5k m² of large

Products & Services

– Continuous Flow Processing
– Chromatography: SMB & Batch
– High Potency (Up to 4 m³ scale & down to 10 ng/m³
containment)
– Energetic Chemistry
– Controlled Substances (Schedule II-V Manufacturing)
– Particle Engineering
– cGMP Manufacturing in Adherent & Suspension Systems for
Viral Vectors
– Analytical & Process Development for Viral Vectors

We provide PAI and full regulatory support.

SOLVAY is a leading manufacturer of fluorinated ALIPHATIC intermediates.

Hans-Boeckler-Allee 20
30173 Hannover
GERMANY

T: +49 511 857-3755
W: http://www.solvay.com/en/markets-and-products/featured-products/Organic-Intermediates.html
E: [email protected]

Solvay

The use of such compounds has grown to become a key component for many blockbusters in the Pharma and Agrochemicals sector. Solvay’s product range covers well known CF3-derivatives like Trifluoroacetylchloride, Trifluoroacetic acid and Triflic acid and it’s derivatives as well as downstream products like 4-Ethoxy-1,1,1-trifluor-3-buten-2-on, some fluorinated Pyrazoles, Pyrimidinones and Pyridones and fluorinated Ionic liquids.

Stoli Chem

Multipurpose and scalable flow reactor technologies for sustainable processes.  Effortlessly taking your process from the lab to pilot to production scale.

Stoli Catalysts Ltd
Prince Phillip Building
Wellesbourne Campus
Wellesbourne
CV35 9EF
UK

Phone:  0800 145 5401
Contact Email:   [email protected]
Webhttps://stolicatalysts.com/
LinkedInhttps://www.linkedin.com/company/stoli-catalysts/

Stoli Chem

Design and develop scalable flow reactors to convert batch chemistry to flow.

Utilising over 15 years of experience in process design and catalysis, Stoli work closely with you to optimise production efficiency.

Our scalable multipurpose flow reactor offers a straight forward route to scale-up from lab to pilot to production scale. The modular design allows for changeable inserts to accommodate liquid-liquid, liquid-gas and solid-liquid reaction types.

Independent stirring and flow rate allow for efficient mixing even at long residence times.

Visit us to discuss how our technology can benefit your company and to organise a reactor trial.

Web:  https://stolicatalysts.com/
LinkedIn:  https://www.linkedin.com/company/stoli-catalysts/

Strem UK  distributes a wide range of bio and catalysts, phosphorus and other ligands, organometallics, ALD/CVD  precursors, and nanomaterials.

Newton Hall
Newton
CB22 7ZE
[email protected]

Strem Chemicals UK Ltd

Strem Chemicals UK Ltd has had a presence in the UK and Ireland for over twenty five years. We distribute a wide range of high purity chemicals and specialty materials.

These include:

  1. A range of metals, inorganics, organometallics and nanomaterials
  2. We offer patent-free and proprietary catalysts and ligands for organic synthesis, often at kilo-scale, including many for asymmetric transformations
  3. For the materials science/electronic community we include a wide range of MOCVD, CVD and ALD precursors & bubblers, metal-based nanomaterials (including PURE nanoparticles that are reactant and surfactant-free) quantum dots (including Graphene) and carbon nanomaterials (nanotubes, fibres, cones, CNT arrays, graphene), rare-earth and electronic grade chemicals for ultra-high purity needs and ionic liquids

Our licensed technologies come royalty-free for R&D purposes.

Our clients include academic, industrial and governmental research laboratories as well as commercial scale businesses in the pharmaceutical, microelectronic and chemical industries.

We are certified compliant to ISO 9001 and 14001.

Syrris is a world leader in high quality, innovative products for research and development chemists and chemical engineers.

27 Jarman Way

Royston, Hertfordshire

SG8 5HW

United Kingdom

 

T: +44 (0) 1763 242 555

W: www.syrris.com

E: [email protected]

Syrris

Syrris takes pride in designing, developing and selling easy to use automated products for chemists in areas such as the pharmaceutical industry, academia, CROs, petrochemical industry etc. Syrris have two major product types: batch reactor systems and flow reactor Systems.

Teledyne

Teledyne is a leading manufacturer of a wide range of innovative products designed to serve the pharmaceutical, academia, and reactant feed sectors.

Teledyne

Teledyne ISCO’s pumps are designed for reaction chemistry, focused on the delivery of pulseless and precise flow in order to ensure the highest yield. If you need precise, positive fluid metering for bench-scale R&D; batch or continuous processing, liquefied gases, or supercritical fluids, take a look at what ISCO Syringe Pumps have to offer. By adding in some of our accessories, you can control the temperature of the fluid or keep the fluids in suspension.

Our line of Flash and HPLC systems includes instruments and accessories for the purification of organic compounds in normal-phase and reversed-phase separations, and for bio-purification of proteins, peptides, and other biopolymers. The ACCQPrep HP 125 is one of our newer additions to our product offering. We also now offer the CombiFlash NextGen line which provides numerous models to choose from based on your budgetary and application needs in flash chromatography performance.

 

Thar Process is the global leader in industrial scale SFC – the most sustainable chromatography technology today. Utilizing CO2, we can save solvent use and disposal by an average of 90% by replacing normal phase solvents for pharmaceutical applications.

Address

150 Gamma Drive,
Pittsburgh,
Pa 15238

Phone

(412) 968-0200

Thar Process

Vapourtec Ltd is an innovative laboratory technology company based near Cambridge, UK

Vapourtec Ltd
21 Park Farm Business Centre
Fornham St. Genevieve
Bury St Edmunds
Suffolk
United Kingdom
IP28 6TS

T: +44 (0)1284 728659
F: +44 (0)1284 728352
E: [email protected]
W: www.vapourtec.com

Vapourtec

Vapourtec develops, manufactures and markets cutting-edge flow chemistry systems for fine chemical discovery and process development. Customers for Vapourtec’s products include blue-chip companies and research institutes developing, pharmaceuticals, agrochemicals, fragrances, advanced materials and other fine chemicals.

WPT is a CRO that specializes in process research and custom GLP/GMP synthesis of organic compounds with full analytical capabilities.

229A Lake Drive

Newark, Delaware

19702

USA

 

T:  + 302-737-9916

W: www.wilmingtonpharmatech.com

E: [email protected]

Wilmington PharmaTech Company

Today, WPT is known as one of the best and fastest API supplier in US or even in the world.

Our capabilities include:

  • cGMP Synthesis
  • Stable Isotope Labeling
  • Bulk Intermediate Production
  • FTE/Time-Based Process and Analytical Research
  • Salt and Polymorph Screening
  • Genotoxic Impurities (GTI’s) and Trace Analysis
  • Analytical GLP/GMP full Services
  • ICH stabilities and sample storage
  • Impurities ID, Preparation and qualification: Process impurities, stability impurities, and metabolites
  • R&D areas: Chiral separation, Continuous Flow Reactions, Nucleotides, Oligonucleotides

Current expansions: US Based pilot production plant, HPAPI suites, and Bioanalysis

WuXi AppTec provides a broad portfolio of R&D and manufacturing services that enable companies in the pharmaceutical, biotech and medical device industries worldwide to advance discoveries and deliver groundbreaking treatments to patients.

WuXi AppTec
55 Cambridge Parkway
8th flr
Cambridge, MA 02142
USA

1 (617) 945 8043
[email protected]
https://www.wuxiapptec.com

WuXi AppTec

WuXi AppTec provides a broad portfolio of R&D and manufacturing services that enable companies in the pharmaceutical, biotech and medical device industries worldwide to advance discoveries and deliver groundbreaking treatments to patients. As an innovation-driven and customer-focused company, WuXi AppTec helps our partners improve the productivity of advancing healthcare products through cost-effective and efficient solutions.

Zaiput Flow Technologies

Zaiput Flow Technologies commercializes groundbreaking proprietary technology that enables continuous, scalable,  membrane based liquid-liquid separation for batch and flow chemistry applications

Zaiput Flow Technologies
4 Gordon Place, Cambridge
MA – 02139 – USA

Ph +1-617-714-9806
www.zaiput.com

Zaiput Flow Technologies

Zaiput Flow Technologies brings to market unique liquid-liquid and gas-liquid technology designed for flow and batch chemistry applications. We offer a scalable separation solution from bench to production. Our devices offer continuous operation, can readily separate emulsions and liquid with identical density. The modularity of the devices allows for both single and multistage operation in a variety of possible configurations

ZEON CORPORATION introduces a new process solvent, Cyclopentyl methyl ether (CPME), which can replace THF, Dioxane, MTBE, etc.

1-6-2 Marunouchi,

Chiyoda-ku,

Tokyo

100-8246 JAPAN

 

T: +81-3-3216-0542     or     F: +81-3-3216-1303

W: http://www.zeon.co.jp

E: [email protected]

ZEON CORPORATION

CPME contributes to Green Chemistry and Process Innovation because of its unique properties including a high hydrophobicity, low peroxide formation and good stability to acids.