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Last week I was in Madrid running our chemical development and scale up course. I met a great group of people, one of whom worked at Dynamit Nobel. During a coffee break we struck up a conversation about (of all things) azides, in particular sodium azide. Fairly quickly we both discovered that we had no READ MORE |
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For the past decade I have been intrigued by the emergence of micelle technology and its ability to enable many organic reactions in water, but perplexed about why the reactions work as effectively as they do, and have been waiting for more universal reaction conditions. Two recent papers address these issues. The title of the READ MORE |
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Several weeks ago I did my annual analysis of the synthetic routes used to prepare small molecule drugs approved by the FDA in the preceding year, obviously in this case 2022.1 I hope those of you who have seen the presentation found it as interesting to watch as I found to put it together. One READ MORE |
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Two principles that we at Scientific Update teach in the foundational “Chemical Development” course are that new experimental methods can open new opportunities for old reactions, and that as scientists we should be looking to understand the mechanisms of empirical observations. Both of these principles are exemplified in by a recent pre-print publication by the READ MORE |
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“How many steps are there in a synthetic route?” is one of the foundational questions for any chemist, but as with many apparently simple questions, the answer isn’t always that simple. In many cases chemists are incentivized to give an artificially low step count because it makes their new route look better and therefore more READ MORE |
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Love it or hate it, triphenylphosphine oxide (TPPO, Figure 1) is something we all encounter at some point during our chemistry careers. Most of the time it’s just a by-product from well-established and widely used process such as the Mitsunobou, Wittig, Staudinger, Appel and Corey-Fuchs reactions.1 I remember having a vial full of the white, READ MORE |
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Nirmatrelvir, the active ingredient of the Pfizer drug Paxlovid (Figure 1), is an inhibitor of the SARS-CoV-2 main protease enzyme.1 A key transformation- the final synthetic step in the synthesis of Nirmatrelvir- is dehydration of a primary amide (Figure 2).The amide starting material is prepared by reaction of the corresponding ester with ammonia.2 Various methods READ MORE |
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Flow Chemistry and Continuous Processing Conference |
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Date: 08 May 2023 - 09 May 2023 Time: 08.45 - 16.00 Location: Boston, USA |
Empowering Women in Organic Chemistry Europe |
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Date: 15 June 2023 - 15 June 2023 Time: 08.30 am - 18.30 pm Location: Manchester |
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Filtration and Drying Course |
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Date: 20 March 2023 - 22 March 2023 Location: Online Platform |
Practical Management of Impurities and Development of Effective and Comprehensive Control Strategies |
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Date: 21 March 2023 - 29 March 2023 Location: Online Platform |
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Introduction to Artificial Intelligence and Machine Learning for Process Chemistry |
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Date: 17 May 2023 Time: 15:00 (BST), 16.00 (CEST), 10.00 (EDT), 7.00 (PDT) |
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