Organic Process Research and Development 2019 |
Date: 23 September 2019 - 25 September 2019 Time: 08.15 - 16.30 Location: Altis Grand Hotel, Lisbon |
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One of the most significant technological advancements in synthetic organic chemistry in recent years is the use of photoredox catalysis to generate synthetically useful radical intermediates and promote novel reactivity. It has the potential to enable exploration of chemical space that remains difficult to access using traditional synthetic methodology and too improve the efficiency of READ MORE |
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There are now 3 cocrystal API’s (Entresto, Suglat, and Depakote) on the market meaning that this area is no longer just an academic curiosity. Entresto is a cocrystal formed from the sodium salts of sacubitril and valsartan, but I do not know whether that is affected by the current furore over N-nitrosoamine impurities found in READ MORE |
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Dr John Studley, Science Director at Scientific Update and Dr Rachel Grainger from Astex Pharmaceuticals got together ahead of our forthcoming Organic Process R&D Conference in Lisbon, Portugal on 23-25 September. Q: Dr John Studley (JS) Can you give us an overview of Fragment Based Drug Discovery (FBDD) and how you see the technique evolving over the next decade? A: READ MORE |
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Dr John Studley, Science Director at Scientific Update and Dr William Goundry from Astra Zeneca got together ahead of our forthcoming Organic Process R&D Conference in Lisbon, Portugal on 23-25 September. Q: Dr John Studley (JS) We are looking forward to your presentation ‘The Good, the Bad and the Ugly! Successes and Failures from the READ MORE |
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When I started my PhD one of my then colleges spent months trying to make something that was sitting on a shelf in the chemical store room less than ten feet from their bench. Could there really be anything more frustrating? Well yes there could. Imagine finding a new catalytic process or synthetic transformation only READ MORE |
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Aryl boronates are among the most widely used synthetic intermediates in the pharmaceutical and agrochemical industries, both in R&D and commercial manufacture.1 Historically these key building blocks have been made using transition metal (Pd, Cu, Ni) catalysed cross coupling reactions between an appropriate aryl halide (usually bromide, iodide or activated chlorides) and an alkoyboron species.2 Efforts to READ MORE |
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The keynote speaker at our recent ‘Polymorphism and Crystallisation’ Conference in Boston was Dr Susan M. Reutzel-Edens from Eli Lilly, whose name will very familiar to anyone working in the solid form / crystallisation and she gave what one delegate described as “the best talk I have ever heard”. Now I can’t entirely agree with READ MORE |
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The use of fluorine and fluorine-containing functional groups in medicinal chemistry, agrochemicals and advanced materials has grown over the past fifty years.1 Not surprisingly this increase in utility tracks with notable developments and refinements in safe and accessible synthetic methodology, both on the discovery and development front and in subsequent manufacturing. A recent example that caught READ MORE |
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Deoxyfluorination remains amongst the most frequently used method for preparing alkyl fluoro compounds.1 The reaction typically involves activation of a leaving group followed by SN2 (but occasionally SN1) reaction with fluoride ion. This is usually accompanied with significant elimination side-reactions and can frequently be low yielding. The original deoxyfluorination reagents such as DAST (diethylaminosulfur-trifluoride) and READ MORE |
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Netarsudil- a ROCK kinase inhibitor marketed by Aerie pharmaceuticals as RhopressaTM– was recently approved by the FDA for ocular hypertension.1 An asymmetric synthesis is challenging due to the aryl group lowering the pKa of the α-hydrogen, rendering it very susceptible to racemization both during synthesis of the amino acid and subsequently amide coupling to an unreactive, poorly READ MORE |
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Xenon (Xe, Element 54) Xenon, from the Greek for ‘stranger’ is a colourless, odourless group 18 noble gas. Discovered in 1898 in London by William Ramsay, xenon is produced commercially by the fractional distillation of liquid air and is isolated as a by-product of the cryogenic production of oxygen and nitrogen. The concentration in the READ MORE |
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Organic Process Research and Development 2019 |
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Date: 23 September 2019 - 25 September 2019 Time: 08.15 - 16.30 Location: Altis Grand Hotel, Lisbon |
6th Winter Process Chemistry Conference |
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Date: 09 December 2019 - 11 December 2019 Time: 12.30pm - 1.00pm Location: The Birmingham Conference & Events Centre, Birmingham, UK |
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Secrets of Batch Process Scale-Up |
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Date: 17 September 2019 - 19 September 2019 Location: Radisson Blu, Dublin |
Practical Management of Impurities and Development of Effective and Comprehensive Control Strategies |
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Date: 26 September 2019 - 27 September 2019 Location: Lisbon, Portugal |
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Alkyl Fluorination | Methods and Materials |
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Date: 18 September 2019 Time: 15:00 (London, BST), 10.00 (New York, ET), 7.00 (San Francisco, PT) - 16:00 |
Novel Bicyclo[1.1.1]pentane (BCP) Fragments, their Roles, Preparation and the Challenges in Synthesis at Scale |
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Date: 09 October 2019 Time: 15:00 (UK, BST) - 16:00 |
Drug Metabolism. Principles for Medicinal Chemists |
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Date: 16 October 2019 Time: 15:00 (London, BST), 10.00 (New York, ET), 7.00 (San Francisco, PT) - 16:00 |
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