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| What’s New in Process Chemistry – Issue 60 April 2017
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| Alkyne to Alkene Reduction
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| The Lindlar reduction of alkynes to alkenes is well known but does not always work as well as we would like, so any new method for carrying out this potentially useful reduction is always of interest. Grela and a co-worker found that Hoveyda-Grubbs HG metathesis catalysts in the presence of NaH (20 mol %) and Read More | |
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| Improving the Substrate Scope of the Kumada-Corriu Cross Coupling Reaction
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| The Ni or Pd catalysed Kumada-Corriu reaction between an aryl halide and a Grignard reagent is one of the original cross coupling reactions, and we all know that the Grignard reagent can react with suitable functional groups, such as carbonyls, on the aryl halide which limits it’s applicability. Buchwald1 and Knochel2 have shown that by Read More | |
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| | Permissible limits for impurities during clinical development has always been a grey area. Existing guidelines, specifically ICH Q3A only formally apply to marketed products. How factors such as duration of clinical trials have never been effectively addressed. Read More | |
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| Iron Catalysis in Organic Synthesis – A Critical Assessment of What it Takes To Make This Base Metal a Multitasking Champion
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| Industrial homogeneous catalytic processes are dominated by the use of expensive precious metals and rely on very efficient catalytic cycles for their cost effectiveness. Many of the processes carried out with precious metals are also achieved by iron catalysis, but often other processes compete and these chemistries have not been so widely used in industry, Read More | |
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| Predicting Greenness Scores
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| This excellent paper from BMS describes a method for predicting the process mass intensity (PMI) for a given chemical step or for a whole synthesis, and thus provides a new way to compare synthetic routes even at the design stage. At the heart of this approach is an internal database of PMI scores for 15 Read More | |
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| Particle Size Control in Batch Crystallisation of Pyrazinamide on Different Scales
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| In the past, the particle size of finished APIs was mostly controlled by processes such as milling and micronization, but this often creates fines and can lead to formulation issues for some compounds. More recently companies are trying to control the particle size of the product as part of the crystallisation process (not forgetting that Read More | |
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