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What’s New in Process Chemistry – Issue 60 April 2017
 
 
Alkyne to Alkene Reduction

The Lindlar reduction of alkynes to alkenes is well known but does not always work as well as we would like, so any new method for carrying out this potentially useful reduction is always of interest. Grela and a co-worker found that Hoveyda-Grubbs HG metathesis catalysts in the presence of NaH (20 mol %) and


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Improving the Substrate Scope of the Kumada-Corriu Cross Coupling Reaction

The Ni or Pd catalysed Kumada-Corriu reaction between an aryl halide and a Grignard reagent is one of the original cross coupling reactions, and we all know that the Grignard reagent can react with suitable functional groups, such as carbonyls, on the aryl halide which limits it’s applicability.  Buchwald1 and Knochel2 have shown that by


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Impurities Guidelines

Permissible limits for impurities during clinical development has always been a grey area. Existing guidelines, specifically ICH Q3A only formally apply to marketed products. How factors such as duration of clinical trials have never been effectively addressed.


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Iron Catalysis in Organic Synthesis – A Critical Assessment of What it Takes To Make This Base Metal a Multitasking Champion

Industrial homogeneous catalytic processes are dominated by the use of expensive precious metals and rely on very efficient catalytic cycles for their cost effectiveness. Many of the processes carried out with precious metals are also achieved by iron catalysis, but often other processes compete and these chemistries have not been so widely used in industry,


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Predicting Greenness Scores

This excellent paper from BMS describes a method for predicting the process mass intensity (PMI) for a given chemical step or for a whole synthesis, and thus provides a new way to compare synthetic routes even at the design stage. At the heart of this approach is an internal database of PMI scores for 15


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Particle Size Control in Batch Crystallisation of Pyrazinamide on Different Scales

In the past, the particle size of finished APIs was mostly controlled by processes such as milling and micronization, but this often creates fines and can lead to formulation issues for some compounds. More recently companies are trying to control the particle size of the product as part of the crystallisation process (not forgetting that


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The Scale-Up of Chemical Processes
21 June 2017 -
23 June 2017

Organic Process Research and Development
27 September 2017 -
29 September 2017

Hazardous Chemistry for Streamlined Large Scale Synthesis
28 November 2017 -
29 November 2017

 
 
Secrets of Batch Process Scale-Up
26 April 2017 -
28 April 2017

Organic Synthesis: A Toolkit for the Industrial Chemist
09 May 2017 -
11 May 2017

Design of Experiments for Chemists and Engineers
16 May 2017 -
17 May 2017

 
 
Crystallization Scale-Up, An Industry Perspective
27 April 2017
Flow Chemistry & Continuous Processes
22 May 2017
Crystallization Process Design and Control
24 May 2017
 
 
 
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