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Newsletter Issue 58 March 2016

Scientific Updates' What's New in Process ChemistryScientific Update
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Aromatic Cyanation


Dr Will Watson

Scheme1 March 2016

C.A. Malapit, J.T. Reeves,* C.A Busacca, A.R. Howell, and C.H. Senanayake (Boehringer Ingelheim), Angew. Chem. Int. Ed., 2016, 55, 326-330.

 

Urea Synthesis


Dr Will Watson

Scheme2 March 2016

S.H. Kim and S.H. Hong,* Org. Lett., 2016, 18, 212-215 

Ozonolysis


Dr Will Watson

Scheme3 March 2016

 

OPRD Conference, Phoenix, AZ, March 10-12, 2016


Dr Will Watson

If you missed the meeting here a couple of highlights, with more to follow next time.

Dr Thomas Colacot of Johnson Matthey gave a very enjoyable and intellectually stimulating presentation on new palladium (Pd) catalysts for cross coupling, which were inspired by the Buchwald second and third generation preformed catalysts.

 

OPRD Conference, Phoenix, AZ, March 10-12, 2016 Cont.


Dr Will Watson

Siyu Tu, of Dow, described the development of a process for separating diastereomeric mixtures of pentane-1,3-diol. The process takes advantage of the different physical properties and reactivity of the acetophenone acetals.

Scheme5 March 2016

Is the Glass Half Full or Half Empty?


Dr Will Watson

The optimist thinks the glass is half full

The pessimist thinks the glass is half empty

The chemist thinks the glass is full – half liquid – half air

The engineer thinks the glass is twice as big as it needs to be

The wine drinker thinks he/she is half way to the next glass of wine

The therapist asks you how you feel about the glass.

Two Recent Reviews on Recent Advances in C-H Activation


Dr Trevor Laird

C-H activation is a hot topic at the moment but process chemists who are thinking of using this technology in synthetic routes will realise that in many cases the need to introduce additional functionalization to direct the incoming group into a particular C-H bond may lengthen the route.

Next Generation of Fluorine Containing Pharmaceuticals


Dr Trevor Laird

Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies; New Structural trends and Therapeutic Areas

Fluoro-organic chemistry is a hot topic at present and about 20% of new pharmaceuticals have a fluorine atom, or sometimes several atoms, in their structure. This excellent review covers the synthetic routes to 51 fluorine-containing molecules that are in development or have been approved since 2011 (Yu Zhou et al, Chem Rev, 2016, 116, 422-518).

 

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