Newsletter Issue 52 Mar/Apr 2014

Understanding Oxygen Sensitivity of a Process at Lab and Manufacturing Scale

Dr Trevor Laird

A great paper in OPRD from Lilly scientists and engineers at Indianapolis and Kinsale, Ireland explains the differences between lab and plant when working with palladium catalysed reactions ...

Forced Degradation Studies Using Anhydrous Conditions

Dr Trevor Laird

Traditional forced-degradation studies use aqueous solutions and are designed to seek out pharmaceutically-relevant degradation mechanisms for drug substances.

Death of Herbert House

Dr Trevor Laird

In the C&E News of Feb 10th 2014, the death of Herbert House was announced.

Batch Kinetics in Flow using online IR Analysis

Dr Trevor Laird

Currently kinetic data is either collected under steady state conditions in flow or by generating time-series data in batch.

Synthesis of Tetrazoles from Alkynes

Dr Trevor Laird

For an interesting mechanistic problem, suggest how this transformation was achieved using a gold catalyst.

TOPICAL TIP

Triphenyl Phosphine Oxide Removal

Dr John Knight

During our OPRD conference in Florida in February, amongst the many excellent talks was one by Kirill Lukin of Abbvie. The talk was fascinating, but one tip in particular really caught my attention.

HIGHLIGHT

Enhanced Simple and Preparative Chromatographic Separations

Dr John Knight

Although there are instances where purification by chromatography is the method of choice (eg enantiomeric separations using SMB is both a powerful and potentially cost-effective option), most process chemists will design and develop processes with the intent to remove the need for purifications by chromatography.

Book reviews

Industrial Process Scale Up; A Practical Innovation Guide from Idea to Commercial Implementation

Dr Trevor Laird

by Jan Harmsen (Elsevier, 2014 ISBN 9780444627261)

BRAINTEASERS

Coffee Break Brainteasers

Dr John Knight

I came across two interesting transformations recently and thought they’d make for interesting brainteasers over a coffee.

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Don't Forget

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Right First Time in Fine-Chemical Process Scale-Up

A Book by Bert Hulshof
495 Pages (A4) £99.50 plus P&P

"...essential reading for all chemists and engineers..."

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The Scale-Up of Chemical Processes

21 - 23 June 2017

Organic Process Research and Development

27 - 29 September 2017

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Practical Approaches to Quality by Design for Pharmaceutical Process R&D and Manufacturing

04 - 06 April 2017

Secrets of Batch Process Scale-Up

26 - 28 April 2017

Organic Synthesis

09 - 11 May 2017

Design of Experiments for Chemists and Engineers (DoE)

16 - 17 May 2017

Secrets of Batch Process Scale-Up

23 - 25 May 2017

Practical Approaches to Statistical Design of Experiments (DoE) for Chemical Process R&D

23 - 24 May 2017

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CONFERENCES

The Scale-Up of Chemical Processes

Organic Process Research and Development

COURSES

Practical Approaches to Quality by Design for Pharmaceutical Process R&D and Manufacturing

Secrets of Batch Process Scale-Up

Organic Synthesis

Design of Experiments for Chemists and Engineers (DoE)

Secrets of Batch Process Scale-Up

Practical Approaches to Statistical Design of Experiments (DoE) for Chemical Process R&D

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