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Newsletter Issue 50 December 2013

Scientific Updates' What's New in Process ChemistryScientific Update
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N,N-Dimethyl Formamide; A Multipurpose Building Block


Dr John Knight

During my reading of the literature I like to look for what I consider more unusual topics or information that could be useful in a different context and for this reason I am often attracted to reports about solvents, looking for the potential for this class of material to act not simply as a carrier or facilitator for our chemistry, but also to participate.

Frustrated Lewis pairs (FLPs)


Dr John Knight

I have periodically mentioned frustrated Lewis pairs (FLPs) in my newlsetter items since I find this a fascinating area of chemical research which may well have great potential to open a new non-metal field of catalysis.

Nickel-Catalysed Cyanomethylation


Dr John Knight

I was attracted to the paper by H Guan et al (Angew Chem Int Ed, 2013, 52 (29), 7523) since it describes what appears to be a nice and convenient means to add the cyanomethyl group to an aldehyde.

Odourless Isocyanide Chemistry Using Continuous Flow


Dr John Knight

Regular readers of my chosen articles will know that I like multicomponent reactions, so it will come as no surprise to note my interest in the paper by P Kim et al (Angew Chem Int Ed, 2013, 52 (29), 7564).

N-Formyl Saccharin As A Carbon Monoxide Source


Dr John Knight

Some time ago I had to scale a palladium-catalysed aminocarbonylation reaction from 10’s of grammes to about 10kg input – the process in this case worked very nicely and we were able to operate at atmospheric pressure as opposed to the 3-5bar used in lab scale by our client.

O-Benzylating Reagent


Dr John Knight

A slightly older article – which I must have missed on first pass!  M Kunishima et al (Org Lett, 2012, 14 (19), 5026) describe the synthesis and use of a novel acid-catalysed O-benzylating reagent.

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