Biocatalysis as a Tool for the Synthetic Chemist

Tutors: Dr Andrew Wells

The aim of the course is to give organic chemists an understanding and an overview of the subject of biotransformations.

Attendees will learn about the main classes of enzymes and the transformations these enzymes carry out.

Each transformation type will be illustrated with examples and case studies and the course will also include problem sessions where attendees will work on real examples applying biotransformations to organic synthesis.

Recent developments in the field will be covered as well as an overview of the sort of equipment and resources required.

Course Outline

Introduction to Biocatalysis
Literature sources for biocatalysis (books and review articles)
Myths about biocatalysis / pros and cons of biocatalysis
Enzyme / protein basics, basic microbiology
Sources of biocatalysts
Equipment requirements
Enzyme types
Hydrolytic Enzymes (Lipases, esterases, amidases, proteases)
Mechanism of hydrolysis by enzymes
Kinetic resolution
Use of organic solvents
Dynamic kinetic resolution (DKR)
Deracemisation
Ester, amide, nitrile and epoxide hydrolysis
concentration
Oxidations
Alcohol oxidation
Amine oxidation, deracemisation of amines and amino acids
Bio-oxygenation, bio-hydroxylation
Demethylation
Epoxidation
Bayer-Villiger oxidation
Sulphoxidation
Reduction
Ketone reduction, Prelog rules
Co-factors
Deracemisation of secondary alcohols
Enantioselective reduction / DKR
Keto-ester reduction
C=C reduction
C-C and C-X bond formation
Aldol reactions
Transketolases
Cross benzoin reactions
Hydroxy-nitrile lyases
Michael reactions
Transamination
Fumarase and aspartase
Scale Up of Biotransformations
Reactors
Case studies
New Developments including Directed Evolution
Polymerase Chain Reaction
Mutagenesis
Directed Evolution
Product isolation
Pros and Cons of Biocatalysis
Summary
Q&A, discussion

Who Should Attend

Any Organic Chemist involved in synthesis, particularly those involved in designing novel, green synthetic routes.Chemists who want to learn how biocatalysis can help them.Those involved in the scale up of biocatalytic reactions.

What's Included

Refreshments & lunch daily
Dinner on the first evening
The comprehensive Course Manual
Course Certificate

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