It was good. Never visited a Scientific Update conference, but will get it on my priority list. Very good – like the set-up, flow and topics. Very interested in process development.
It was good. Never visited a Scientific Update conference, but will get it on my priority list. Very good – like the set-up, flow and topics. Very interested in process development.
It was good. Never visited a Scientific Update conference, but will get it on my priority list. Very good – like the set-up, flow and topics. Very interested in process development.
Last month I posted a scheme from a paper by a team from Merck describing the synthesis of a soluble guanylate cyclase (cGC) stimulator of interest for the treatment of hypertension and asked if you could identify reagents or intermediates B, F, and the target compound H. Below are the answers! You can read more here in the full reference: S. Raghavan et al, Bioorg. Med. Chem. Lett. 2020, 30, DOI: 10.1016/j.bmcl.2020.127574
In this post I’m highlighting a couple of papers that are essentially two sides of the same coin. As a process chemist, I’ll be the first to admit that the chemistry I’m about to describe is not going to end up in your manufacturing route any time soon, but as a former card-carrying medicinal chemist…
In George Orwell’s classic 1945 novella ‘Animal Farm’ the revolutionary livestock develop the slogan “Four legs good, two legs bad” to summarize their views on the farmer and other humans. As the novella progresses, we see that things cannot be simplified so readily, and so I was encouraged by the recent excellent article by Brianna…
The introduction of bromine into intermediates is a key transformation in the synthesis of pharmaceuticals and other high value materials, due to the reactivity and selectivity it offers for further transformation, over for example the generally cheaper, more common but less reactive chlorinated analogues. Bromine is commonly introduced by one of three reagents: bromine itself…
