Archived: VIRTUAL Conference | The Scale-Up of Chemical Processes

WHO SHOULD ATTEND?

• Process Development & Production Chemists
• Chemical Engineers in Industry
• Technical Managers
• Quality Assurance Personnel
• Safety Specialists 
• Heads of Departments & Team Leaders

HOW WILL YOU BENEFIT FROM ATTENDING?

• Benefit by hearing from key speakers who will present detailed case studies.
• Learn from a wide range of academic and industrial case studies given by our hand-picked industrial speakers.
• Access how industry strategies are evolving to meet today’s challenges.
• Learn how your peers are developing solutions to common problems.
• Gather important information on technical developments and equipment.
• Bring yourself up-to-date on current developments and future trends in pharmaceutical development.
• Meet and network with the key people working in the pharmaceutical industries – during our discussion sessions.
• Save time by picking up essential tips from experts in their fields.

SESSION  1 |  2.00 – 2.45 pm (BST)  Choose one from the following:

• Room 1 |  Mettler Toledo

Data-rich Experimentation to Accelerate Development Time

Chemical process development and scale-up from the lab to a commercial scale presents challenges including engineering, safety, and economics. Join us for a panel discussion and hear about real-life scale-up challenges from 3  industry experts, Ron Carasquillo, BMS, Keith Mattern, Merck, and Dave Place, Pfizer. Learn how the their application of PAT for data-rich experimentation (DRE) improved process understanding, facilitating optimization and scale-up to commercial scale.

• Room 2 | Scale Up Systems

Mixing workshop: From lab to plant, scale-up tips and methodologies

Mixing can affect all processes which have competing rate processes, like parallel consecutive reactions or crystallizations.  In this session our experts will discuss how to understand the importance of mixing on scale-up performance for your key processes responses.  We will share a protocol to efficiently identify mixing issues that can affect process responses on scale, with some examples of how this has been used in pharmaceutical and fine chemical companies.

We will then show how typical mixing criteria can be efficiently predicted using simulation tools and how those scale-dependent parameters can be layered on top of scale-independent reaction to kinetics to predict critical quality attributes such as yield and selectivity for right-first-time scale-up.

• Room 3 | Concept Life Sciences

Candidate nomination: What’s next? Managing risk and return on investment in early development.

Our experts will begin with a short presentation on a real life case study for a first GMP campaign, followed by a panel discussion on key questions around strategies in early development to maximise return on investment and minimise risk.  The discussion will touch on the topics and challenges below:

1. The data gathered in discovery must be verified and solidified in early development. Quality data allows confidence to fail fast or proceed and invest with confidence. Which areas do you focus on first to ensure your firm foundation?
2. A candidate molecule (usually!) comes with a synthetic route. If it is possible to deliver sufficient material for your next set of development work, what factors would you consider before investing in route design?
3. The “developability” of a compound is often influenced by the solid form and ultimately the formulation selected. How can we set ourselves up for success in early development? What are the key challenges we will have to overcome in solid form selection, salt form selection and pre-formulation activities? What can guide us where to start?

SESSION  2  |  3.00 – 3.45 pm (BST)  Choose one from the following:

Room 4 |  Phosphonics

Optimising scavenging processes for more sustainable and cost effective chemical processes

Catalysis is ubiquitous in the chemical industry and is a key pillar of green chemistry. We will discuss with the attendees their use of catalysis, showing how scavenging can be a more cost effective solution than most people imagine. We will share our approach to optimising cost effective scavenging processes and share case studies on the removal of metal impurities to meet the ICH guidelines as well as the recovery of value from waste streams for more cost effective and sustainable catalytic processes. 

Room 5 | Kaneka

Enabling Manufacturing with Enzymes and Flow Chemistry – Robust Route Development for Successful Scale-Up

With 50 years experience in researching, engineering, and scaling up commercial scale biosynthesis, this discussion group will focus on typical issues and questions associated with exploring biocatalysis as a tool for small molecule synthesis.  This includes screening approaches, barrier to entry, scale capabilities, and using ‘off the shelf’ vs a custom enzyme approach.

We will also cover the research and scale-up of continuous manufacturing methods, including the ability to scale enzymatic processes into a continuous process through immobilization.

Real lab and commercial scale case studies will be provided as a means for discussion.

Room 6  |  Mettler Toledo

Interfacing PAT with Reactors, and Integration and Management of Data

With all the challenges chemical process development and scale-up from the lab to a commercial scale presents, we are often asked very practical questions – “How complicated is it to interface a PAT probe with a reactor?”, or “How does one manage and use the dense data that is collected?”. Join us for a live discussion to review frequently asked questions about taking the next steps in implementing PAT and data management strategies for scale-up studies and processes.

CONFERENCE SPONSORS

Thank you to our Conference Sponsors, for more information on our sponsors please visit our Virtual Exhibition 

5* Sponsors

4* Sponsors

3* Sponsors

We now only have 3* sponsorship opportunities available for this conference.

Please contact Dr Claire Francis for more information

Oril Industrie

Thank you very much for this well-organized conference.

Japan Tobacco Inc

Excellent conference, good staff, good venue. I’m very satisfied.

Hovione

The place to be! A great way to talk about challenges and advances in process scale-up.