1. Using an approved drug as a diazomethane surrogate1 A recent paper published in Angewandte Chemie describes the use of Temozolomide (TMZ) as a solid weighable diazomethane surrogate. TMZ is an approved drug and is the standout treatment for gliobastoma. It is stable weighable solid, with reasonable water solubility. Under physiological conditions , pH 7.4,
Category: Will’s Corner
There are now 3 cocrystal API’s (Entresto, Suglat, and Depakote) on the market meaning that this area is no longer just an academic curiosity. Entresto is a cocrystal formed from the sodium salts of sacubitril and valsartan, but I do not know whether that is affected by the current furore over N-nitrosoamine impurities found in
How many named organic reactions do you think we can find in biological systems? 10-20, 20-30, 30-40, or 40-50? The answer can be found in this review in Angewandte¹. C.-I. Lin, R.M. McCarty, and H.-w. Liu, Angew. Chem. Int. Ed., 2017, 56, 3446-3489.