In 1981 Oppolzer published a short, racemic synthesis of Lysergic acid. Below is a scheme of the early steps in the synthesis. Can you identify reagents or intermediates G, I and H? Answers and a reference will be posted in late June, along with another problem. Enjoy!  

Last month I posted a scheme from a paper by a team from Merck describing the synthesis of a soluble guanylate cyclase (cGC) stimulator of interest for the treatment of hypertension and asked if you could identify reagents or intermediates B, F, and the target compound H. Below are the answers! You can read more here in

A recent paper by a team from Merck describe the synthesis of a soluble guanylate cyclase (cGC) stimulator of interest for the treatment of hypertension. Can you identify reagents or intermediates B, F and the target compound H? Answers and a reference will be posted in May, along with another problem. Enjoy!

Last month I posted a scheme from a paper by Jonathan H. George et al at the University of Adelaide describing a biomimetic total synthesis of the Rhododendron meroterpenoids rubiginosins A and G and asked if you could identify reagents or intermediates B, D, E and H. Below are the answers! You can read more here

Did you know that we have a ‘Job Area’ on our website? If you have a vacancy and are looking for a process chemist or chemical engineer, why not post your position on our website? We have 1,000’s of visitors looking at our site for process chemistry training and events, so thought this is an

A recent paper by Jonathan H. George et al at the University of Adelaide describes a biomimetic total synthesis of the Rhododendron meroterpenoids rubiginosins A and G. Can you identify reagents or intermediates B, D, E and H? Answers and a reference will be posted in a month, along with another problem. Enjoy!    

As businesses around the world have had to postpone and cancel live meetings, conferences and training courses in response to COVID-19 disease, workplace and group training has become one of the earliest and hardest-hit business activities. We have found that 100% of companies we work with across the globe, have had to postpone or cancel their

In an effort to support and highlight the outstanding contributions of Women in Process Chemistry, the journal Organic Process Research & Development has decided to publish a Special Issue that will aim to highlight a select collection of papers from Women in the field of Process Chemistry. As a co-editor for this Special Topic Issue,

Interview with Technical Director Dr Will Watson from Scientific Update on CKHTV Chemicals Knowledge Hub TV

Mayfield, UK | March 15th 2020 With major events cancelling across Europe and the US over the past few days, we know that many of our customers are asking questions about our forthcoming training courses and conferences. With the increasing number of Covid-19 cases and travel restrictions / bans, we have a duty of care