In this paper (Gonzalez et al., Org. Process Res. Dev. 2019, 23, 6, 1143-1151) from the Chemical and Synthetic Development team at Bristol-Myers Squibb, DoE and QbD methodologies have been used to develop a telescoped process for the API step in the route to a reversible inhibitor of BTK. (Scheme 1) Scheme 1: Two step

Multipurpose facilities for batch processing remain ubiquitous in the process industries for relatively short campaigns of diverse products.  Whether the products be active pharmaceutical ingredients, foods, agrochemicals, or other fine and specialty chemicals, those producing them face a  shared problem: how to satisfactorily remove residues of the previous campaign from the plant before commencing on

When it comes to thermal hazard assessment, differential scanning calorimetry (DSC) takes a special place in the landscape of possible testing methods. Both for rapid screening of a wide variety of samples, and for the gathering of the necessary high-quality data for a detailed kinetic study of decomposition reactions, DSC is usually the instrument of

Many years ago, I heard an anecdote regarding a fortuitous discovery in the Sharpless lab. A graduate student had been awarded their PhD and the group were celebrating in the lab with bottles of red wine (I know- but they were different times). Someone in the group-who had obviously consumed a sufficient quantity of the

During the past few years the application of electrochemical methods for organic synthesis attracted increasing attention both in academia and industry.1 Electroorganic synthesis rely on interaction of the starting materials with electrodes in an electrochemical cell to realize redox chemistry. As inert an inexpensive substances, such as water, can be used as electron donor and