Crystallisation and Polymorphism and Related Issues

Our experts have worked on the development and scale up of processes involving crystallisations and have carried out troubleshooting, particularly for companies making the less stable polymorphic forms, in manufacturing.  Advice on how to tailor the process to produce the desired form and particle size distribution has led to very successful scale ups for our clients.

We can advise on salt screening and selection of the most appropriate salt for development and formulation, whether solid or solution/suspension.  This is followed by form screening for polymorphs and solvates, particularly hydrates, and advice on the best form to develop, with API manufacturing and formulation in mind.  Amorphous solids are more prevalent as molecular complexity increases and we have advised on technologies to ensure efficient manufacture such as spray drying and freeze drying (lyophilisation).

We assist with and advise on the selection of a CRO where a client does not have the in-house capability or expertise for solid state work and can then help manage the project.

We teach courses on Polymorphism and Crystallisation and these courses have been particularly designed for development chemists and engineers, with emphasis on the scale up of processes to produce consistently the desired form.